Tuesday, March 31, 2020

CoronaVirus- What make it deadly?

CoronaVirus- What make it deadly?

Coronavirus has exceptionally large single-stranded RNA genomes - approximately 26,000 to 32,000 bases or RNA "letters". Coronavirus particles are surrounded by a fatty outer layer, called an envelope and usually appearing spherical, as seen under an electron microscope, with a crown of club-shaped spikes or "corona" on their surface.

Coronaviruses are a group of viruses that commonly cause mild diseases, such as the common cold. However, some types of coronaviruses can infect the lower airways, causing serious diseases such as pneumonia or bronchitis. Most people are infected with coronaviruses at some point in their lives and most of these infections are harmless. A notable exception is the new coronavirus that causes Kovid-19 disease.

Covid -19

Third party image reference

The virus that causes Covid-19 is known as SARS-CoV-2. It emerged for the first time in Wuhan, China in late 2019. The outbreak has since spread to China and other countries around the world. By the end of January,

Coronaviruses replicate their RNA genome using an enzyme called RNA-dependent RNA polymerase, which is prone to errors, but genomic analyzes so far suggest that Kovid-19 is slowly mutating, making it more lethal. The most commonly reported symptoms include fever, dry cough, and fatigue, and in mild cases people may simply have a runny nose or sore throat. In the most severe cases, people with the virus can cause difficulty breathing, and eventually experience organ failure. Some cases are fatal.

Source -Google image (Free to reuse)

There are currently no vaccines or specific drug treatments for coronavirus, but efforts are underway to develop the vaccine and HIV and Ebola drugs are being tested in people with Kovid-19. On March 18, the World Health Organization (WHO) said they have begun testing the most promising drugs, including the long-used antimalarial drugs chloroquine and hydroxychloroquine, a new antiviral drug called Dadsvir And the combination of the two HIV drugs is called lopinavir and lopinavir. ritonavir. HIV drugs will also be tested in combination with an antiviral called interferon beta.

On 22 March, several countries in Europe, including the UK, began a collaborative trial of the same drugs, which would complement WHO's efforts.Several other potential treatments are being explored, most notably the possibility of developing antibodies against Kovid-19.


Other severe coronavirus

At least two other types of human coronavirus - Middle East respiratory syndrome coronavirus (MERS-CoV) and severe acute respiratory syndrome coronavirus (SARS-CoV) - are known to cause severe symptoms.

SARS-CoV first emerged in 2002 in Guangdong, China as an uncommon pneumonia, which in some cases developed into fatal respiratory failure. The virus quickly spread to 29 countries, infecting more than 8000 people and killing about 800.

The MERS-CoV pandemic appeared in Saudi Arabia in 2012, with people experiencing similar symptoms to SARS-CoV, but dying at a high rate of 34 percent. In contrast to SARS-CoV, which spreads quickly and widely, MERS-CoV is mainly restricted to the Middle East.


Spread from animals to people

Source -Google image (Free to reuse)

Coronaviruses are zoonotic, meaning they can be transmitted from animals to people. Both SARS-CoV and MERS-CoV originally came from bats, although other animals - including camels in the case of MERS - may act as intermediaries that spread coronaviruses to humans. Many of the early cases of Covid-19 were traced back to a large seafood and animal market in Wuhan. The viruses are thought to have come from bats, possibly through a intermediary animal.

People may experience:

1-cough

2-fever

3-tiredness

4-difficulty breathing (severe cases)

In starting phase virus stick in throat of infected person for 3-4 days. Corona form a thick mucus which block all air vent which cause problem in breathings, for short time artfical breathing through ventilator can help patients.


For India we can do

India

Total case - 1,071

New Case +47

Death -29 +2

Total recovered -100

Active case -942

Total case/1M popouation -0.80.

First case reported -02Jan 29

Sources-https://www.worldometers.info/coronavirus/


Source -Google image (Free to reuse)

1-Pray to God

2-Wash hand with soap/sanitizer regularly

3-Avoid gathering, function, visit and traveling and follow lockdown rules

4-Take proper balanced food and proper sleep and include giloy and tulsi in moderate quantity, they can enhance immunity.

5-Social distancing is necessary but don't follow social boycotting person.

6-Don't relate disease with any community, religion or region


-Use handkerchief, napkins while sneezing or covered your mouth with hands.

8-Use sanitizer while outside.

9-If possible please use mask (N95 or any other) and surgical gloves in public, it will not cure but reduce chances of spread.* Mask does not prevent spread completely but it reduces the chances.

10-If feel irritation in throat gargles with salt water, as these virus remain 3-4 days in throat.

11-Practice personal hygiene as much as possible.

12-Sanitize door handle, mobile and daily use items

13-Make compulsory to all wash hand before entering home.

14-If possible use neem oil and camphor burning in home..(some say there is no scientific evidence ) but ancient vedic system insist on yagya, hawan on curing infection related to virus and bacteria.

15- Avoid public transport as much as possible. In case of emergency use personal or private vehicle.

16- Try to do , work from home.

17- if you are room owner, then don't threaten your tenants for room rent , try to postpone for next month.

18- If you are factory owner, then allow your employee to work from home


Don't do

1-Dont Spread fake news

2-Dont watch news channel in excess because they used to traumtize common people.

3-Dont hoader items unnecessarily but keep essential items such as grain, vegetable and milk in sufficient quantity.

4-Don't post YouTube video, tik tok video giving tricks to break lockdown because this is not

CURFEW but "care for you "

5-Dont link this virus with religion as say our religious does not permit such testing.

6-Don't try to escape out, from quarantine centre.

7-Avoid travelling by air or train as much as possible.

8-Don't blame government or any particular person like Modi for all, only to prove your point.

9-Don't support religious fanatics and remain in home / self isolation.

10-Don't post rumours on social media.


Disclaimer- Don't follows any post blindly including mine, take consultation from medical practitioner. These are small precautions only and it is collected from different internet sources, we do not claim for acuteness or originality.

Saturday, February 29, 2020

Things to know about Corona Virus



Third party image reference
Read in detail
 Corona viruses are types of viruses that commonly affect the respiratory tracts of birds and mammals, including humans. Doctors associate them with the common cold, bronchitis, pneumonia, and severe acute respiratory syndrome (SARS), and they can also affect the bowels.
Over the past 70 years, scientists have found that corona viruses can infect mice, rats, dogs, cats, turkeys, horses, pigs and cattle. Sometimes, these animals can deliver corona virus to humans.
Recently, authorities identified a new corona virus outbreak in China that has now reached other countries. It is named Corona virus disease 2019, or COVID-19.
These viruses are usually responsible for more common cold than serious diseases. However, corona viruses are also behind some of the more severe outbreaks.
In this article, we explain various types of human corona viruses, their symptoms and how they are transmitted to people. We also focus on three particularly dangerous diseases that spread due to corona virus: COVID-19, SARS and MERS.

What is Corona virus?



Third party image reference
Researchers first isolated a corona virus in 1937. They found a corona virus responsible for an infectious bronchitis virus in birds that had the potential to destroy poultry stocks.
Scientists first found evidence of human corona virus (HCoV) in the nose of people with the common cold in the 1960s. Two human corona virues are responsible for a large proportion of the common cold: OC43 and 229E.
The name "coronavirus" comes from crown-like projections on their surfaces. "Corona" in Latin means "halo" or "crown".
In humans, corona virus infection often occurs during the winter months and early spring. People regularly get sick from cold due to coronavirus and can catch the same after about 4 months.
This is because corona virus antibodies do not last long. In addition, antibodies to one strain of corona virus may be ineffective against another.

Symptoms

Cold- or flu-like symptoms usually occur 2–4 days after corona virus infection and are usually mild. However, the symptoms vary from person to person, and some forms of the virus can be fatal.
Symptoms include:
Sneeze
running nose
fatigue
cough
fever in rare cases
sore throat
severe asthma
Scientists cannot easily cultivate human corona virus in the laboratory unlike rhinoviruses, which is another cause of the common cold. This makes it difficult to understand the impact of corona virus on national economies and public health.
There is no cure, so treatment includes self-care and over-the-counter (OTC) medication. There are several steps people can take, including:
• Relax and avoid redundancy
drink enough water
• Avoid smoking and smoke areas
• Taking acetaminophen, ibuprofen or naproxen for pain and fever
• Using a clean humidifier or cool mist vaporizer
A doctor can diagnose the responsible virus by taking respiratory fluid, such as mucus from the nose, or a sample of blood.

Type



Third party image reference
Submili in the Coronaviridae of the Corona viruses family belong to Coronavirinae.
Different types of human corona viruses differ in how severe the resulting disease becomes, and how far they can spread.
Doctors currently recognize seven types of corona viruses that can infect humans.
Common types include:
• 229 E (alpha coronavirus)
• NL63 (alpha coronavirus)
• OC43 (beta coronavirus)
• HKU1 (beta coronavirus)
Rare strains that cause more serious complications include MERS-CoV, which causes Middle East Respiratory Syndrome (MERS), and SARS-CoV, the virus responsible for severe acute respiratory syndrome (SARS).
In 2019, a dangerous new strain called SARS-CoV-2 began to spread, causing the disease COVID-19.

The transfer

Limited research is available on how HCoV is transmitted from one person to another.
However, researchers believe that viruses are transmitted through fluids in the respiratory system, such as mucus.
Corona virus can be spread in the following ways:
• Coughing and sneezing without covering the mouth can spread droplets into the air.
• Shaking or shaking hands with a person who has the virus can pass the virus between individuals.
• Making contact with a surface or object that contains the virus and then touching the nose, eye, or mouth.
• Some animal corona viruses, such as feline corona virus (FCoV), can spread through contact with feces. However, it is not clear whether this also applies to human corona viruses.
The National Institutes of Health (NIH) suggests that COVID-19 has the highest risk of developing complications in many groups of people. These groups include:
young children
• 65 years of age or older
• Women who are pregnant
Corona viruses will infect most people at some time during their lifetime.
Corona viruses can mutate effectively, which is what makes them so contagious.
To prevent transmission, people should stay at home and rest when symptoms are active. They should also avoid close contact with other people.
Covering the mouth and nose with a tissue or handkerchief while coughing Or sneezing can also help prevent transmission. Disposal of any tissue after use and maintenance of hygiene around the house is important.

COVID-19

In 2019, the Centers for Disease Control and Prevention (CDC) began monitoring outbreaks of a new coronavirus, SARS-CoV-2, causing respiratory disease now known as COVID-19. Authorities first identified the virus in Wuhan, China.
More than 74,000 people have contracted the virus in China. Health officials worldwide have identified several others with COVID-19, many from the United States. On January 31, 2020, viruses spread from person to person in the U.S.
The World Health Organization (WHO) has announced a public health emergency related to COVID-19.
Since then, this strain has been diagnosed in many US residents. The CDC has advised that it is likely to spread to more people. COVID-19 has started causing disruption in at least 25 other countries.
The first people with COVID-19 had an animal and seafood market. This fact suggested that animals initially transmitted the virus to humans. However, people with more recent diagnoses had no connection with or in contact with the market, confirming that humans could pass the virus to each other.
Virus information is currently scarce. In the past, respiratory conditions that develop from coronaviruses, such as SARS and MERS, have spread through close contact.
On February 17, 2020, the Director General of WHO presented in a media how often the symptoms of COVID-19 are severe or fatal, using data from 44,000 people with confirmed diagnoses:
Stage of severity of people with COVID-19
Mild disease, from which a person can recover more than 80%
Serious illness, which causes breathlessness and pneumonia around 14%
Serious illness including septic shock, respiratory failure and multiple organ failure
Fatal disease 2%
The Director-General also stated that the risk of serious complications increases with age. According to the WHO, some children receive COVID-19, although they are still investigating its causes.
However, while some viruses are highly contagious, it is less clear how fast the coronavirus will spread.
Symptoms vary from person-to-person with COVID-19. It can cause few or no symptoms. However, it can cause serious illness and can be fatal. Common symptoms include:
fever
breathlessness
cough
It may take 2–14 days for a person to notice symptoms after infection.
There is currently no vaccine available for COVID-19. However, scientists have now replicated the virus. This may allow early detection and treatment in those who have the virus but are yet to show symptoms.

Sars

SARS was an infectious disease that developed after infection by SARS-Cove Coronavirus. Usually, this poses a life-threatening form of pneumonia.
During November 2002, the virus began in southern China's Guangdong province, eventually reaching Hong Kong. From there, it quickly spread worldwide, causing infections in more than 24 countries.
SARS-CoV can infect both the upper and lower respiratory tract.
SARS symptoms develop over the course of a week and begin with fever. At the onset of the condition, people develop flu-like symptoms, such as:
dry cough
chills
diarrhea
breathlessness
• Pain
Pneumonia, a serious lung infection, usually develops. In its most advanced stage, SARS causes lung, heart, or liver failure.
According to the CDC, officials marked 8,098 people contracted SARS. 774 of these infections were fatal. This is equivalent to a mortality rate of 9.6%.
Older adults were more likely to have complications, and half of all people over the age of 65 who became ill were not alive. The authorities eventually controlled the SARS in July 2003.

MERS

MERS spread due to a coronavirus known as MERS-CoV. Scientists first identified this serious respiratory disease in 2012 after surfacing in Saudi Arabia. Since then, it has spread to other countries.
Virus us , While the largest outbreak outside the Arabian Peninsula occurred in South Korea in 2015.
Symptoms of MERS include fever, shortness of breath, and cough. The disease is spread by close contact with people who already have an infection. However, all cases of MERS have links to individuals returning from a recent trip to the Arabian Peninsula.

Sunday, July 07, 2019

ONE DAY: JUSTICE DELIVERED MOVIE REVIEW


ONE DAY: JUSTICE DELIVERED MOVIE REVIEW

Directed by    Ashok Nanda
Produced by  Ketan Patel, Kamlesh Singh KushwahaSwati Singh
Written by     Alaukik Rahi
Starring         Anupam Kher, Esha Gupta, Kumud Mishra,Nasirr Khan, Anusmriti Sarkar
BP Rating        2.0/5.0



Story: 

This is a kind of thriller in which a retired judge (Anupam Kher) is forced to take the law into his own hands to ensure justice. Meanwhile, ACP Lakshmi Rathi (Isha Gupta) tries to solve the mystery of some missing persons on her own. Now, will they be able to fulfill their respective missions or face disappointment?

One Day:Justice Delivered
One day-Justice Delivered (www.bankimpandey.ooo)


Review: 

This is the story of a retired judge Tyagi (Anupam Kher), who work with vigilance after retirement, to punish all the culprits, who were running the streets free of a scout because of lack of evidence against them. Solitaire was bound by law to decide on some matters which they thought were unfair. And a special event shakes him from inside and when he takes matters into his own hands and goes on the mission to remove the confession from all those criminals.



One Day:Justice Delivered
 In the beginning, it looks like a good cautious thriller, but soon an average affair becomes. The point is that when we can catch some well-cooked thrillers, then why to wait for this half-truth story of justice.The whole story is quite intriguing, but the direction directed by Ashok Nanda is sluggish and dissatisfied, especially the first part. The second half, however, raises the speed and makes it an interesting watch. Performance as a retired judge by Anupam Kher is quite promising and so is the inspector Sharma (Kumud Mishra) too. Isha has played similar D-Glam role in another movie of 2012, but this time, she outlines her past performance as a tough cop. The only thing that looks like a total misfit is that it is a Hariyanavi tone, which is not convincing at all.



In addition, when a series of missing cases related to high-profile persons tell Laxmi Rathi (Isha Gupta) Special Officer of Crime Branch, she decides to investigate this matter. The music is easily forgotten because there is no such song with the story, which is also in addition to the title track sung one day sung by Usha Uthup - the legendary singer is in her element.

Conclusion

Don't expect too much from the film